Ergogenic response to caffeine in resistance performance, perceived pain, and female sex hormones following muscular endurance in strength-trained eumenorrheic females during early follicular phase
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This study investigates the ergogenic response to caffeine, in terms of repetitions to failure, time under tension, perceived pain, and female sex hormones (oestradiol and progesterone), following muscular endurance during the early follicular phase. Eleven strength-trained eumenorrheic females performed two consecutive trials (48 h apart). Using a double-blind crossover design, participants were randomly assigned to receive either caffeine (4 mg/kg) 1 h before exercise or a placebo. In each trial, participants performed as many repetitions of leg extension and hip adduction as possible at 65% of 1-RM. Two minutes of recovery were allocated between each exercise. Each repetition was performed at maximal velocity. Perceived pain was rated on an 11-point scale immediately after each exercise, and blood samples were drawn from each participant 30 min after completing the test. Data revealed a significant ergogenic response to caffeine in repetitions to failure for leg extension and hip adduction (p = .003 and p = .043, respectively); meanwhile, caffeine led to a significantly longer time under tension in leg extension (p = .001), with no differences in hip adduction (p = .053). In terms of perceived pain, no differences between trials were found for hip adduction (p = .724), but it was rated higher after leg extension in the caffeine trial, when compared to the placebo (p = .011). No differences were observed between trials regarding oestradiol and progesterone levels (p = .138 and p = .350, respectively). In conclusion, ingestion of 4 mg/kg of caffeine increased leg extension and hip adduction repetitions to failure, without main effects on perceived pain and sex hormones, in strength-trained eumenorrheic females during the early follicular phase.
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References
Adan, A., Prat, G., Fabbri, M., & Sànchez-Turet, M. (2008). Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences. Progress in neuro-psychopharmacology & biological psychiatry, 32(7), 1698-1703. https://doi.org/10.1016/j.pnpbp.2008.07.005
Aguiar, A. S., Jr, Speck, A. E., Canas, P. M., & Cunha, R. A. (2020). Neuronal adenosine A2A receptors signal ergogenic effects of caffeine. Scientific reports, 10(1), 13414. https://doi.org/10.1038/s41598-020-69660-1
Arazi, H., Hoseinihaji, M., & Eghbali, E. (2016). The Effects of Different Doses of Caffeine on Performance, Rating of Perceived Exertion and Pain Perception in Teenagers Female Karate Athletes. Brazilian Journal of Pharmaceutical Science, 52. https://doi.org/10.1590/s1984-82502016000400012
Arnaud M. J. (2011). Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handbook of experimental pharmacology, (200), 33-91. https://doi.org/10.1007/978-3-642-13443-2_3
Banks, N. F., Tomko, P. M., Colquhoun, R. J., Muddle, T. W. D., Emerson, S. R., & Jenkins, N. D. M. (2019). Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia. Scientific reports, 9(1), 10532. https://doi.org/10.1038/s41598-019-46931-0
Beck, T. W., Housh, T. J., Schmidt, R. J., Johnson, G. O., Housh, D. J., Coburn, J. W., & Malek, M. H. (2006). The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. Journal of strength and conditioning research, 20(3), 506-510. https://doi.org/10.1519/18285.1
Bellar, D., Kamimori, G., & Glickman, E. (2011). The Effects of Low-Dose Caffeine on Perceived Pain During a Grip to Exhaustion Task. Journal of Strength and Conditioning Research / National Strength & Conditioning Association, 25, 1225-1228. https://doi.org/10.1519/JSC.0b013e3181d9901f
Bowtell, J. L., Mohr, M., Fulford, J., Jackman, S. R., Ermidis, G., Krustrup, P., & Mileva, K. N. (2018). Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants. Frontiers in nutrition, 5, 6. https://doi.org/10.3389/fnut.2018.00006
Davis, J. K., & Green, J. M. (2009). Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports medicine (Auckland, N.Z.), 39(10), 813-832. https://doi.org/10.2165/11317770-000000000-00000
Davis, J.-K., Green, J. M., & Laurent, C. M. (2012). Effects of Caffeine on Resistance Training Performance on Repetitions to Failure. Journal of Caffeine Research, 2(1), 31-37. https://doi.org/10.1089/jcr.2012.0005
Del Coso, J., Muñoz, G., & Muñoz-Guerra, J. (2011). Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 36(4), 555-561. https://doi.org/10.1139/h11-052
Diaz-Lara, F. J., Del Coso, J., García, J. M., Portillo, L. J., Areces, F., & Abián-Vicén, J. (2016). Caffeine improves muscular performance in elite Brazilian Jiu-jitsu athletes. European journal of sport science, 16(8), 1079-1086. https://doi.org/10.1080/17461391.2016.1143036
Duncan, M. J., Stanley, M., Parkhouse, N., Cook, K., & Smith, M. (2013). Acute caffeine ingestion enhances strength performance and reduces perceived exertion and muscle pain perception during resistance exercise. European Journal of Sport Science, 13(4), 392-399. https://doi.org/10.1080/17461391.2011.635811
Elliott, K., Cable, N., Reilly, T., & Diver, M. (2004). Effect of menstrual cycle phase on the concentration of bioavailable oestradiol and testosterone and muscle strength. Clinical Science (London, England : 1979), 105, 663-669. https://doi.org/10.1042/CS20020360
Ferré S. (2016). Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders. Psychopharmacology, 233(10), 1963-1979. https://doi.org/10.1007/s00213-016-4212-2
Filip-Stachnik, A., Wilk, M., Krzysztofik, M., Lulińska, E., Tufano, J. J., Zajac, A., Stastny, P., & Del Coso, J. (2021). The effects of different doses of caffeine on maximal strength and strength-endurance in women habituated to caffeine. Journal of the International Society of Sports Nutrition, 18(1), 25. https://doi.org/10.1186/s12970-021-00421-9
Goldstein, E., Jacobs, P. L., Whitehurst, M., Penhollow, T., & Antonio, J. (2010). Caffeine enhances upper body strength in resistance-trained women. Journal of the International Society of Sports Nutrition, 7(1), 18. https://doi.org/10.1186/1550-2783-7-18
Graham, T. E., & Spriet, L. L. (1995). Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Journal of applied physiology (Bethesda, Md.: 1985), 78(3), 867-874. https://doi.org/10.1152/jappl.1995.78.3.867
Granfors, M. T., Backman, J. T., Laitila, J., & Neuvonen, P. J. (2005). Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2. Clinical Pharmacology & Therapeutics, 78(4), 400-411. https://doi.org/10.1016/j.clpt.2005.06.009
Grgic, J., & Mikulic, P. (2017). Caffeine ingestion acutely enhances muscular strength and power but not muscular endurance in resistance-trained men. European journal of sport science, 17(8), 1029-1036. https://doi.org/10.1080/17461391.2017.1330362
Grgic, J., Grgic, I., Pickering, C., Schoenfeld, B. J., Bishop, D. J., Virgile, A., & Pedisic, Z. (2020). Infographic. Wake up and smell the coffee: caffeine supplementation and exercise performance. British journal of sports medicine, 54(5), 304-305. https://doi.org/10.1136/bjsports-2019-101097
Grgic, J., Pickering, C., Del Coso, J., Schoenfeld, B. J., & Mikulic, P. (2021). CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review. European journal of nutrition, 60(3), 1181-1195. https://doi.org/10.1007/s00394-020-02427-6
Lara, B., Gutiérrez Hellín, J., Ruíz-Moreno, C., Romero-Moraleda, B., & Del Coso, J. (2020). Acute caffeine intake increases performance in the 15-s Wingate test during the menstrual cycle. British journal of clinical pharmacology, 86(4), 745-752. https://doi.org/10.1111/bcp.14175
Martins, G. L., Guilherme, J. P. L. F., Ferreira, L. H. B., de Souza-Junior, T. P., & Lancha, A. H., Jr (2020). Caffeine and Exercise Performance: Possible Directions for Definitive Findings. Frontiers in sports and active living, 2, 574854. https://doi.org/10.3389/fspor.2020.574854
McCall, A. L., Millington, W. R., & Wurtman, R. J. (1982). Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport. Life sciences, 31(24), 2709-2715. https://doi.org/10.1016/0024-3205(82)90715-9
McLean, C., & Graham, T. E. (2002). Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women. Journal of Applied Physiology, 93(4), 1471-1478. https://doi.org/10.1152/japplphysiol.00762.2000
Mitchell, D. C., Knight, C. A., Hockenberry, J., Teplansky, R., & Hartman, T. J. (2014). Beverage caffeine intakes in the U.S. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 63, 136-142. https://doi.org/10.1016/j.fct.2013.10.042
Mohr, M., Nielsen, J. J., & Bangsbo, J. (2011). Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation. Journal of applied physiology (Bethesda, Md. : 1985), 111(5), 1372-1379. https://doi.org/10.1152/japplphysiol.01028.2010
Norum, M., Risvang, L. C., Bjørnsen, T., Dimitriou, L., Rønning, P. O., Bjørgen, M., & Raastad, T. (2020). Caffeine increases strength and power performance in resistance-trained females during early follicular phase. Scandinavian journal of medicine & science in sports, 30(11), 2116-2129. https://doi.org/10.1111/sms.13776
Notbohm, H. L., Moser, F., Goh, J., Feuerbacher, J. F., Bloch, W., & Schumann, M. (2023). The effects of menstrual cycle phases on immune function and inflammation at rest and after acute exercise: A systematic review and meta-analysis. Acta Physiologica, 238(4), e14013. https://doi.org/10.1111/apha.14013
Polito, M. D., Grandolfi, K., & de Souza, D. B. (2019). Caffeine and resistance exercise: the effects of two caffeine doses and the influence of individual perception of caffeine. European journal of sport science, 19(10), 1342-1348. https://doi.org/10.1080/17461391.2019.1596166
Raastad, T., Bjøro, T., & Hallén, J. (2000). Hormonal responses to high- and moderate-intensity strength exercise. European journal of applied physiology, 82(1-2), 121-128. https://doi.org/10.1007/s004210050661
Richardson, D. L., & Clarke, N. D. (2016). Effect of Coffee and Caffeine Ingestion on Resistance Exercise Performance. Journal of strength and conditioning research, 30(10), 2892-2900. https://doi.org/10.1519/JSC.0000000000001382
Romero-Moraleda, B., Del Coso, J., Gutiérrez-Hellín, J., & Lara, B. (2019). The Effect of Caffeine on the Velocity of Half-Squat Exercise during the Menstrual Cycle: A Randomized Controlled Trial. Nutrients, 11(11), 2662. https://doi.org/10.3390/nu11112662
Sabblah, S., Dixon, D., & Bottoms, L. (2015). Sex differences on the acute effects of caffeine on maximal strength and muscular endurance. Comparative Exercise Physiology, 1, 1-6. https://doi.org/10.3920/CEP150010
Salinero, J. J., Lara, B., Jiménez-Ormeño, E., Romero-Moraleda, B., Giráldez-Costas, V., Baltazar-Martins, G., & Del Coso, J. (2019). More Research Is Necessary to Establish the Ergogenic Effect of Caffeine in Female Athletes. Nutrients, 11(7), 1600. https://doi.org/10.3390/nu11071600
Sampaio-Jorge, F., Morales, A. P., Pereira, R., Barth, T., & Ribeiro, B. G. (2021). Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists. Scientific reports, 11(1), 24327. https://doi.org/10.1038/s41598-021-03158-2
Smilios, I., Tsoukos, P., Zafeiridis, A., Spassis, A., & Tokmakidis, S. P. (2014). Hormonal responses after resistance exercise performed with maximum and submaximum movement velocities. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(3), 351-357. https://doi.org/10.1139/apnm-2013-0147
Warren, G., Park, N., Maresca, R., McKibans, K., & Millard-Stafford, M. (2009). Effect of Caffeine Ingestion on Muscular Strength and Endurance: A Meta-Analysis. Medicine and Science in Sports and Exercise, 42, 1375-1387. https://doi.org/10.1249/MSS.0b013e3181cabbd8
Wilk, M., Krzysztofik, M., Maszczyk, A., Chycki, J., & Zajac, A. (2019). The acute effects of caffeine intake on time under tension and power generated during the bench press movement. Journal of the International Society of Sports Nutrition, 16(1), 8. https://doi.org/10.1186/s12970-019-0275-x